Microfluidizer© Processor High Shear Homogenisers

Microfluidizer® Processor High Shear Homogenisers

Introducing the all new Microlyser™ Production Scale Cell Disruptor

The MP350 Enhanced Biopharma Grade Microlyser™ processor delivers uniform pressure up to 30,000 PSI. This hybrid solution maximises protein yields and ensures high product quality in cell disruption of various cell types including bacterial, yeast and algae.

The Microlyser™ Processor has the same multi-slotted fixed-geometry Interaction Chambers™ that all Microfluidizer equipment possesses, ensuring repeatable results batch-to-batch at production volumes.

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Microfluidizer® Processor High Shear Homogenisers are the gold standard in uniform nanoemulsions, cell disruption and uniform particle size reduction. Microfluidization offers many advantages over High Pressure Homogenisers including: ease of use, cooling efficiency, easy cleaning and scalability.

Microfluidizer® technology seamlessly scales up from batch to lab, pilot and even production volumes. Whether you are producing nanoemulsions, pursuing delicate cell disruptions, creating suspensions or generating cutting-edge liposomes, Microfluidizer® Processor High Shear Homogenisers is the right equipment for the job.

As the exclusive UK and Ireland distributor of Microfluidizer® Processors from US manufacturer Microfluidics, we provide extensive technical and servicing support to ensure that you get the most out of your investment.

Browse Microfluidizer® Processor High Shear Homogenisers below. Alternatively, call us on +44(0)1954 232 776 or email info@analytik.co.uk to discuss your requirements with a specialist.

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How does a Microfluidizer® work? View this 4 minute video to find out!

Microfluidizer® Processors

Lab & Benchtop Machines

High shear homogenisers designed for lab-scale processing. From investigatory R&D to small-scale production, our laboratory homogenisers from Microfluidics offer consistency, scalability and efficiency in small-scale homogenisation.

LM10

LM20

M110P

LV1

Pilot & Production Machines

Our pilot and production-scale homogenisers offer seamless scale-up in pharmaceutical, biotech, chemical, costmetic and food processing applications.

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Applications

Nanoemulsions

Superior Nanoemulsion Technology Yields Better Results

Microfluidizer® Processor High Shear Homogenisers are capable of producing nano-emulsions with a tiny droplet size and narrow distribution, ideal for stability and filtration.

Microfluidics’ diverse product portfolio offers lab machines that can process samples as small as 2 ml and fixed geometry interaction chambers ensure that the process can be scaled up to hundreds of litres per hour on the production scale machines. Microfluidizers are designed to be simple to use and clean with the option of conforming to CGMP requirements.

Cell Disruption

Exceptional Performance vs. Other Techniques

Microfluidizer® Processor High Shear Homogenisers are great for the homogenisation of cells because they are tough on cells and gentle on proteins. Microfluidizer® technology is ideally suited for effectively rupturing cells with different shear requirements- including: E. coli, mammalian, plant, insect, fungi, algae and yeast cell disruption — while ensuring high protein recovery. These capabilities allow researchers to use the lowest pressure possible to reach target rupture rates while avoiding protein denaturation.

To find out more, visit our Solutions for Cell Disruption page.

Polymer Nanoparticles

Ideal Technology for Producing Polymer Nanoparticles

The experts at Microfluidics are available to help customers develop polymeric nanoparticle applications using Microfluidizer^® technology. With the knowledge of how to create small, sterile, filterable nanoparticles, they will demonstrate why a Microfluidizer® processor is the best option for manufacturing certain therapeutics.

Particle size analysis is often used to evaluate polymer nanoparticles. Utilising specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer® technology is able to reduce polymer droplet size significantly after several passes.

Polysaccharides

The Best Method for Molecular Weight Reduction

Use of a Microfluidizer® Processor High Shear Homogeniser for mechanical sizing is superior to chemical methods of molecular weight reduction. Chemical processing can modify the polysaccharide chemical structure, often resulting in highly polydisperse polymers.

A Microfluidizer® processor reduces the molecular weight without altering the chemical structure of the polysaccharide or its attached groups. Because Microfluidizer® technology exposes all the material to the same high shear conditions within the fixed-geometry interaction chamber, the final product is very homogenous with low polydispersity.

Particle Size Reduction

Achieving Uniform Target Particle Sizes on a Nanoscale

With particle sizes typically 50% smaller than those produced by conventional homogenisers and other methods of particle size reduction, a Microfluidizer® processor enables you to achieve:

Improved bioavailability
Targeted drug delivery
Easier downstream processing

Nanoencapsulation

Microfluidizer Technology Provides a Competitive Edge

Customers using Microfluidizer® processor technology for nanoencapsulation applications enjoy competitive differentiation for their products and processes:

Smaller particle sizes
Uniform particle size distribution
Efficient encapsulation rates
Effective cooling
Precise shear
Controlled mixing intensity of reactant streams
Ease of use, cleaning and maintenance
Scale-up guaranteed

Liposomes

Microfluidizer Technology Successfully Processes Liposomes

Microfluidizer® Processor High Shear Homogenisers offer an ideal solution for the production of liposomal formulations due to the following advantages:

Continuous process
Guaranteed scalability using Microfluidizer® interaction chamber technology
Optimal temperature control
Samples are processed at a constant shear rate
Highest shear rate capability of any homogenizer

De-agglomeration

Achieving Successful De-agglomeration in Various Industries

Whether your application requires deagglomeration, dispersion, delamination, exfoliation or defibrillation, Microfluidizer® processors provide an efficient solution.

Unmatched results by directly applying extremely uniform high shear forces to the materials
The amount of shear applied to the material is easily varied to achieve the desired result
Able to process much higher solid concentrations
Particles are typically uniformly dispersed in a single pass
Particle size distribution is reduced
No contamination
Scale-up is guaranteed

Our microfluidizer® processor customers

The LM20 Microfluidizer processor offers superior lysis over traditional methods of cell disruption with an efficient system to reduce internal blockages. The scalability of the design means that the forces experienced by cells will not change if the sample volume increases. I can, therefore, have confidence that the sample quality, yield and processing times won’t be impacted by scaling up my lab processes.

Digital controls allow the system pressure to be set more easily and accurately compared to alternative manual processors, reducing the potential for errors and increasing reproducibility.

Analytik’s in-depth user training, and easy operation/maintenance procedures have been extremely beneficial. I feel confident to troubleshoot and perform preventative maintenance without having to call the support teams – it doesn’t feel like a ‘black box’ machine.

I would recommend the LM20 Microfluidizer as an essential tool for cell disruption.

James Wright, Protein Scientist at Abcam Plc

“Originally we worked with a French press and Gaulin homogenizer, but they posed contamination and equipment cleaning problems. After a demonstration here at our lab, [the Microfluidizer processor’s] performance and sterilization features convinced us to get one immediately”

Stephen Cameron, Quality Assurance Manager , Microtek International

We approached Analytik to find a replacement for a high-pressure homogeniser from another manufacturer, which had been unreliable and failed to achieve sufficient lysis of our tough yeast cells even after very many passes. We selected the LM20 Microfluidizer not only because it efficiently lysed a broad range of cell types but also was incredibly simple and easy to use which is very important as many different people need to use the machine regularly.

We also much appreciated the knowledgeable technical and applications support provided by Analytik which has enabled us to fully exploit the considerable capabilities of the LM20 Microfluidizer.

Dr Petra Ungerer, Lab Manager, School of Biological & Chemical Sciences at Queen Mary University London

“I had been using a competitor system to perform 100-500 ml E. coli lysis for more than a year during my PhD.

When I switched over to a Microfluidizer lysis machine, the difference was night and day. Breakage efficiency was higher and instrument blockage from particulates in the lysis buffer was far less problematic. A Microfluidizer machine made processing E. coli lysates much more convenient, so I could worry about enzyme function rather than production.

Analytik took care of installing a machine that was manufactured and shipped from North America, which went smoothly. We very much enjoyed having the Analytik engineer onsite working to install and train us to use the system. ”

Dr Michael Chen, Co-founder and CCO, Nuclera Nucleics

Lab testing Services

Let us demonstrate how Microfluidizer® Processor High Shear Homogenisers can achieve your nanomaterial processing and product quality goals.

Microfluidics have fully equipped laboratories with lab to production-scale processors and a wide variety of interaction chambers for comparative results. Their highly trained specialist application engineers are experienced in working with different materials and optimising many types of processes.