Free Webinar: Sterile Filtration of Complex Fluids: Challenges & Optimisation Using A Liposomal Model Fluid

Complex fluids such as liposomes are increasingly being used as a vehicle for drug delivery, but due to their nature, efficient and large-scale manufacturing can be challenging.  One such challenge is sterile filtration, both from a throughput and bacterial retention standpoint.

Producing liposomes with precisely controlled particle size and distribution ensures an efficient downstream sterile filtration process. To overcome sterile filtration challenges appropriate decisions must be made during the selection, evaluation, and validation of filters intended for the sterilisation of liposome-based drugs.

Date: Thursday, March 19, 2020

Time: 3:00 p.m. GMT

Event type: Webinar – Live

Language: English

Pall Life Sciences

Presenters:
• Martha Folmsbee PhD, Principal Scientist – Pall Corporation
• Aude Iwaniec, R&D Engineer II – Pall Biotech
• Kelley McCabe, Senior Applications Engineer – Microfluidics International Corporation

Overview:

Complex fluids such as liposomes are increasingly being used as a vehicle for drug delivery, but due to their nature, efficient and large-scale manufacturing can be challenging.  One such challenge is sterile filtration, both from a throughput and bacterial retention standpoint.

Producing liposomes with precisely controlled particle size and distribution ensures an efficient downstream sterile filtration process.  To overcome sterile filtration challenges appropriate decisions must be made during the selection, evaluation, and validation of filters intended for the sterilization of liposome-based drugs.

Participants Will Learn:

  • The challenges of sterilising liposome-based drugs prior to filling.
  • A scalable method for producing liposomes with cGMP capability.
  • Critical process parameters for sterilising filtration of complex fluids.

Shown an example of how to optimise sterile filtration of complex fluids and increase filter throughput.

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