NanoFlowSizer® | In Process Nanoparticle Size Characterisation

The NanoFlowSizer is an innovative system for inline nanoparticle size characterisation that provides continuous, real-time nanoparticle size characterisation of colloidal systems, nanosuspensions, nanoemulsions and other dispersed nanoproducts directly in manufacturing processes (inline), or laboratory settings (offline).

Key Benefits:

  • Continuous size characterisation of nanoparticles during processing
  • Non-invasive measurement – ideally suited for continuously monitoring (sterile) processes
  • Provides real-time process feedback – for increased control over the production process
  • Measures highly turbid materials
  • Rapid measurement – average particle size and size distributions typically provided every 10 seconds
  • Suitable for a wide range of suitable sample volumes

As exclusive distributor for the UK and Ireland, Analytik is proud to supply the NanoFlowSizer® from InProcess-LSP. For more information, or to discuss your requirements with a product specialist, please call us on +44 (0)1954 232 776 or email info@analytik.co.uk.

Description

Continuous, real-time in-process Nanoparticle Size Characterisation with the NanoFlowSizer®

The NanoFlowSizer is a powerful non-invasive Process Analytical Tool allowing close monitoring of particle size characteristics in your process, in either development laboratories, pilot plants or commercial operations, without the need of sampling. The NanoFlowSizer can be integrated easily in your process by using flow-through cells allowing high speed measurements of even highly turbid nanomaterial using new Spatially Resolved Dynamic Light Scattering (SR-DLS) technology* and smart XsperGo software.

*View the Method tab to find out more.

The NanoFlowSizer provides unique opportunities for studying particle size dynamics supporting your product and process development. The system can also be operated in offline mode for manual measurements under static and flow conditions using cuvettes or other glassware.

NanoFlowSizer measurements are performed through glass preventing any direct contact or interference with the sample, which makes the technology ideally suited for continuously monitoring (sterile) processes.

The modular NanoFlowSizer system is highly flexible and customisable, so you can adapt the system to your own specific needs.

 

XsperGo: inhouse developed Software

Software features

The NanoFlowSizer is operated by the inhouse developed XsperGo software.

The NanoFlowSizer records spatially resolved data at high frequency in a continuous mode. The XsperGo software unravels large data amounts into meaningful particle size information. Besides particle size information other relevant information such as temperature readings and viscosity profiles are managed in XsperGo as well.

xspergo-software-features

Interested in NanoFlowSizer technology? Request a quote or call us on +44(0)1954 232 776 to discuss your requirements.

Method

Dynamic light scattering (DLS) is an accepted technology for measuring particle size and size distribution of nanoparticles in liquids. It is based on measurement of fluctuations in light scattering caused by Brownian motion of suspended particles. For Brownian diffusion, the frequency of scattered intensity fluctuations depends on the particle size; smaller particles diffuse more rapidly and thus produce higher frequencies. Therefore, the temporal fluctuations in light scattering hold information on the particle size.

Standard DLS measurements need to be performed under static conditions ensuring that particle movement is solely caused by Brownian motion and not influenced by other factors like liquid flow. Additionally, standard DLS cannot be applied to the turbid suspension which are often encountered in industrial or process environments. This limits the use of standard DLS for inprocess applications.

These limitations can be overcome by the new concept of Spatially Resolved Dynamic Light Scattering (SR-DLS) which allows particle size characterization in process flows and for highly turbid suspensions. The NanoFlowSizer technology is based on low coherence interferometry providing light scattering information as function of optical pathlength in process flows. The depth resolved light scattering holds information on particle movement caused by both Brownian motion as well as flow rate. The contribution to scattered light fluctuations due to Brownian motion is used for calculation of the particle size characteristics.

Other key advantages of the NanoFlowSizer are the capability to distinguish single from multiple scattered light, and the high measurement speed. The XsperGo software automatically identifies and selects single scattered light allowing measurement of highly turbid suspensions in flow. Additionally, the high data-information content and high speed processing, provide characteristics such as mean particle size and distribution typically within 10 seconds. These clear advantages make the NanoFlowSizer the ideal solution for inline measurements, providing continuous real-time process feedback on nanoparticle size characteristics, a powerful Process Analytical Tool.

SR-DLS without Flow

SR-DLS without flow: (left) temporal depth resolved scattering data as basis for (right) auto correlation functions showing single and multiple scattering regimes. The single scattering regime is automatically identified and used for particle size characterisation.

SR-DLS with Flow

SR-DLS with flow: (left) temporal depth resolved scattering data as basis for (right) auto correlation functions showing flow related decorrelation for increasing depth in a flow cell. The flow contribution is determined and compensated for, allowing size characterisation using only the diffusive contribution.

Applications

The NanoFlowSizer has applictaions in a range of sectors including:

  • Pharma/Biopharma
  • Chemical
  • Food
  • Mineral
  • Cosmetics
  • Inks
  • Coatings

Ideal applications include:

  • Lipid-based Nanoparticles:
    • Liposomes, Micelles
    • Emulsions
      • Dairy Products
    • Lipid nanoparticles:
      • Delivery Systems for mRNA Vaccines
  • Protein Molecules
  • Silica, Iron, Titanium Dioxide, Gold Particles
  • Polymers

Videos

An Introduction to NanoFlowSizer Technology

 

About SR-DLS

 

Downloads

PDF Icon NanoFlowSizer® In Process Nanoparticle Size Characterisation Brochure

PDF Icon NanoFlowSizer® FAQs

PDF Icon Real-time Droplet Size Monitoring of Nanoemulsions during High Pressure Homogenization Whitepaper

Articles & Papers

PDF Icon New unique PAT method and instrument for real-time inline size characterization of concentrated, flowing nanosuspensions

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