RAMANview Microscope

RAMANview Microscope

High speed Raman imaging analysis of a tablet

High speed Raman imaging analysis of a tablet

Analysis of crystallinity distribution of resin molded product

Analysis of crystallinity distribution of resin molded product

RAMANview MicroscopeHigh speed Raman imaging analysis of a tabletAnalysis of crystallinity distribution of resin molded product

RAMANview

Substantially extend your view with a unique Raman imaging system. RAMANview provides you with a whole new dimension for easy to use operation and ultra-fast screening!

“Ultra-wide field-of-view”, “Extended depth of focus”, “High spatial resolution”, “Ultra-long working distance” – these 4 values inside the minimum body enable diverse Raman spectroscopic analysis.

Analytik delivers Raman microscopes to the UK and Ireland from Nanophoton.

We will be happy to work together with you on a solution with the full support of the Nanophoton team. Visit our contact page, request a quote, or call us on +44 (0)1954 232 776.

Product Description

The RAMANview raman microscope

RAMANview - a new dimension to Raman imaging

Outstanding usability derived from the pursuit of optimised design

The huge workspace is the result of an optimised, reduced to the most constructive and fundamental criteria of design and functionality. Most modern minimalism for highest usability!

RAMANview - sophisticated design and usability

Technical Specifications:

RAMANview
Wavelength532 nm, 671 nm and others
Objective lens0.5x, 1.0x, 2.0x
IlluminationLED reflection
Focal length of the spectrograph350 mm
Grating (selectable with the order)600 gr/mm, 1200 gr/mm, 2400 gr/mm
Size (W × H × D)300 mm × 610 mm × 720 mm (Baseplate included)
Weight35 kg (Baseplate included)
Sample size (Φ x H)90 x 25 mm
Performance
0.5x objective1.0x objective2.0x objective
Field-of-view (FOV)25.6 × 34 mm 12.8 × 17 mm 6.4 × 8.5 mm
FOV of Raman imaging25 × 25 mm 12.5 × 12.5 mm 6.2 × 6.2 mm
Spatial resolution12 μm 6 μm 3 μm
Working distance70.5 mm 60 mm 20 mm
Spectrum merasurement range100~3200 cm-1 (Option: 50 cm-1~)
Spectral pixel resolution1 cm-1@2400gr/mm,
2 cm-1@1200gr/mm,
4 cm-1@600gr/mm

Request a quote for the RAMANview or call on UK: +44 (0)1954 232 776 / IE: +353 (0)144 751 70.

Applications

RAMANview, the wide-field Raman microscope has changed the common knowledge of space scaling of Raman imaging. A brand new world of applications has been broadened.

High speed Raman imaging analysis of a tablet

Raman imaging of the whole surface of a tablet

RAMANview is a perfect tool for Raman imaging of tablets even with a 1 mm difference in height. Within only 14 minutes, an area of about 100 mm2 was analysed with the 1x objective. A greater difference can be done with the 0.5x objective. Nanophoton’s laser line scanning technology creates this unsurpassed speed with excellent high precision.

Raman imaging of a tablet inside a blister pack

Raman imaging of a tablet inside a blister pack

Even the imaging and analysis of a tablet inside a blister pack is possible by RAMANview. The fixation of a tablet inside the pack cannot be flattened by shaving. Fixation is also impossible, so by moving the stage the tablet will swing inside the blister pack and a Raman analysis would not be possible. Only the unique technology of RAMANview can perform fast imaging under such conditions.

Highly precise Raman imaging analysis of tablet

High-definition Raman images of two different tabletsHigh-definition Raman imaging, which is realised by point illumination with small scanning steps, is recommended for observing distribution of components precisely. The data shown on the right are the high-definition Raman images of 2 different types of antipyretic tablets. Fast laser beam scanning provides high imaging speed. The component distribution is clearly observed by the high spatial resolution over a wide range. Going even beyond, for a small amount of components, like the API’s in tablets, an additional particle analysis is available. The software identify the particles one by one and a statistical analysis of diameter, area and volume is provided.

Particle size analysis of caffeine during formulation

Detect 1% API among the pharmaceutical formulation content

Detect 1% API among the pharmaceutical formulation content

The image above shows the component distribution of a tablet. RAMANview’s 2x objective lens is able to detect the slight amount of APIs (0.5mg) during solid dosage form by means of both a high spatial resolution and wide-area scanning.

Analysis of powder inside a plastic bag

Analysis of powder inside a plastic bag

The deep depth of focus is a great tool for bulky samples, however, even an analysis inside thin plastic bags are greatly performed with RAMANview. Raman peaks from thin film, which can be a noise for micro-Raman system, are not included in a spectrum obtained by RAMANview.

Analysis of crystallinity distribution of resin molded product

Analysis of crystallinity distribution of resin molded product

The FWHM of polyethylene terephthalate’s peak at around 1720cm-1 changes due to the degree of crystallinity. The image above visualises the difference in the degree of crystallinity from the mouth to the body part of PET bottle.

Observation of the composition distribution of Inada granite’s surface

Observation of the composition distribution of Inada granite's surface

The red, blue and green parts are known as quartz, biotite and feldspar respectively from the Raman spectrum. Deterioration and erosion of the rock can be captured with a centimeter-order field-of-view by RAMANview.

*This sample has been provided by Professor Satoru Nakajima of Osaka University.

Observation of the distribution of SiC crystal polymorphism

Observation of the distribution of SiC crystal polymorphism

The image above shows the distribution of polymorphic changes from 4H to 6H of a SiC crystal surface. RAMANview, equipped with wide field-of-view objective lens and fast laser beam scanning, is the best analytical tool for the analysis of the polytypic distribution over a wide range in just 10 minutes.

Crystal quality analysis of diamond

Crystal quality analysis of diamond

The image above shows an analysis example of a diamond file. Diamond has a sharp peak at 1330cm-1, whereas amorphous carbon which is an artificial diamond has a broad peak. It is also applicable to analysis of large-area DLC film.

Datasheet

PDF Icon RAMAview datasheet

The one and only performance

“Ultra-wide field-of-view”, “Extended depth of focus”, “High spatial resolution”, “Ultra-long working distance” – these 4 values inside the minimum body enable diverse Raman spectroscopic analysis.

More than 800 mm2 is analysed without moving the sample

Example of field size of wide-field Raman imaging

RAMANview has a dedicated optical system, which substantially expands the field-of-view. Even large samples – bigger than 800 mm2 – can be analysed without moving the sample. Just select the area of interest and the ultra-fast laser scanning system will do the requested analysis. Regular mapping systems take a long time; there is a risk of moving the sample out of area or even sloping it. RAMANview saves your time and provides a secure analysis of any area of interest.

Be free from time-consuming focus corrections by extended focal depth

Raman imaging of side surface of a tabletThe dedicated optical system of RAMANview provides an extended depth of focus of up to about 1.4 mm (with the 0.5x objective) for samples even with a height difference of 1 or 2 mm without misting out the focus areas. This unique depth of focus enables easy-of-use sampling without sectioning or cutting the sample.

The relationship between magnification of objective lens and depth of focus

The relationship between magnification of objective lens and depth of focus

*Parameters are not specifications. They are indications of typical performance and will vary with each unit NanoPhoton manufacture.

Tiny, micro scale components will be detected with RAMANview

Spatial resolution assessment of RAMANviewThe dedicated optical system creates a high precision spot size, which facilitates a spatial resolution of up to 2.5 μm (see right figure) with the 2x objective lens. RAMANview also stands for very fast Raman imaging in a micro scale range.

Comparison of spatial resolution between RAMANview and RAMANtouch (SiC crystal polymorphs)

Comparison of spatial resolution between RAMANview and RAMANtouch (SiC crystal polymorphs)

Ultra-long working distance extends the measurement scene

Measurement of a sample in a H 45mm vialRAMANview has a working distance of more than 70 mm (with the 0.5x objective). It offers an easy-to-use sampling (safe distance between lens and sample) and allows measurements even in deep containers, vessels or in extensive sampling systems. Even measurements through windows or transparent films etc. are not an issue. RAMANview gives you the space you need for your sampling!

The relationship between magnification of objective lens and working distance

The relationship between magnification of objective lens and working distance

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