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Microfluidics’ Technology

Microfluidics, part of IDEX Corporation, are manufacturers of unique high pressure homogeniser fluid processors, that are the gold standard in nano-enabled applications for uniform particle size reduction, cell disruption and nanoemulsion formation.

40 years serving customers worldwide with over 3000 machines for 2000 customers. Over 1,100 pharmaceutical companies, including 19 of the top 20, 9 of the top 10 biotech and 4 of the top 5 chemical companies own Microfluidics technology.

The Microfluidizer Operating Principle Diagram

                The Microfluidics Technology Resume

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The innovative technology solutions offered by Microfluidics are used globally by laboratories for synthesis and formulation, as well as for production. The combined performance and scalability of Microfluidics equipment is well known and acknowledged in the world of nanotechnologies.

Formulation and production of nanoparticles are used in a wide variety of applications:

  • Pharmaceuticals – such formulations are used to improve the bio-availability,
    stability, administration and efficiency of drugs
  • Biotech – for the efficient extraction of nucleic acids and proteins with prevention of denaturation.
  • Chemicals – nanoparticle properties are used for high-tech components, coatings, inks, fuel cells,
    photovoltaics, composite materials, thin film preparation and more.
  • Food – for encapsulation and delivery of nutraceuticals, and development and manufacture of
    nanoemulsion-type products for “slimming food” markets.
  • Cosmetics – nanoparticles support efficiency and penetration of products through the skin barrier.

The Microfluidizer Benefits:

  • Narrowest particle size distibution – with no moving in-line parts, the fixed-geometry interaction chamber enables a consistent and predictable processing environment with little or no downtime. The chamber combines with a constant pressure pumping system to provide a uniform processing environment for the entire product volume.
  • Repeatabilityreproducible results, batch to batch, day to day. Every milliliter of your sample undergoes the same processing and for this reason results are consistent and reproducible each and every time.
  • Highest Shear Forceduring processing, the product stream accelerates to very high velocities, creating shear
    rates (up to 10-7 s-1) and impact forces within the interaction chamber that are orders of magnitude greater than any other conventional means. This makes the Microfluidizer processor ideal for applications that require extremely small particle sizes, thorough deagglomeration and high yield cell disruption.
  • Scalability –  in production units, identical interaction chamber microchannels are aligned in parallel to ensure uniform processing even at high volumes – often in a 24×7 continuous process. By utilising a linear scale-up method of the fixed-geometry interaction chambers, customers are guaranteed to achieve uniquely consistent results.
  • High efficiency cell disruption –  microfluidizer processors enable extremely effective cell disruption (often >99% rupture for E.coli in only one pass), with high protein recovery. Protein integrity is maximised by the Microfluidizer processor’s low temperature rise coupled with highly effective cooling provided by submerging the interaction chamber and placing a heat exchanger immediately downstream of the interaction chamber.